In Diablo 4, Uniques and Mythic Uniques (often referred to as Uber Uniques) are some of the most powerful and rarest items available in the game. Here's an overview of what you need to know:

Differences Between Uniques and Mythic Uniques

Uniques: These are powerful, class-specific or general items, which can be traded between players.

Mythic Uniques: These are extremely rare, non-tradable items that must be farmed from high-level enemies or bosses. They often have a chance to drop from Tormented Bosses like Duriel and Andariel.

Mythic Uniques (All Classes)

Mythic Uniques drop from World Tier 4 content and are typically farmed from Tormented Bosses. These items are guaranteed to drop with maximum rolls on their affixes and can also have Greater Affixes.

Andariel's Visage - (World Tier 4)

Ahavarion, Spear of Lycander - Druid, Sorcerer (World Tier 4)

Doombringer - (World Tier 4)

Harlequin Crest - (World Tier 4)

Melted Heart of Selig - (World Tier 4)

Ring of Starless Skies - (World Tier 4)

The Grandfather - Barbarian, Necromancer (World Tier 4)

Tyrael's Might - (World Tier 4)

Uniques (For All Classes)

These Uniques can be found in World Tier 3+ and are available from bosses and world events such as Infernal Hordes.

Azurewrath - (World Tier 3+)

Crown of Lucion - (World Tier 3+)

Fists of Fate - (World Tier 3+)

Flickerstep - (World Tier 3+)

Frostburn - (World Tier 1+)

Mother's Embrace - (World Tier 1+)

Paingorger's Gauntlets - (World Tier 1+)

Penitent Greaves - (World Tier 1+)

Temerity - (World Tier 3+)

Class-Specific Uniques

Sorcerer

Axial Conduit (World Tier 3+)

Flamescar (World Tier 3+)

Iceheart Brais (World Tier 1+)

The Oculus (World Tier 3+)

Rogue

Asheara's Khanjar (World Tier 3+)

Condemnation (World Tier 1+)

Eyes in the Dark (World Tier 1+)

Skyhunter (World Tier 1+)

Barbarian

100,000 Steps (World Tier 1+)

Arreat's Bearing (World Tier 3+)

Gohr's Devastating Grips (World Tier 1+)

The Butcher's Cleaver (World Tier 1+)

Druid

Airidah's Inexorable Will (World Tier 1+)

Fleshrender (World Tier 3+)

Tempest Roar (World Tier 3+)

Vasily's Prayer (World Tier 1+)

Necromancer

Black River (World Tier 3+)

Bloodless Scream (World Tier 1+)

Deathless Visage (World Tier 1+)

Ring of Mendeln (World Tier 3+)

How to Get Uniques & Mythic Uniques

Uniques: Farm bosses like Duriel, Andariel, Grigoire, and world events like Nightmare Dungeons, Infernal Hordes, and Hellgates.

Mythic Uniques: Focus on Tormented Bosses and World Tier 4. High-level enemies and bosses above level 55 have a small chance to drop them.

Crafting Mythic Uniques

You can also craft Mythic Uniques using Resplendent Sparks, which are earned by salvaging other Mythic items or completing seasonal milestones.

Crafting Cost: 4 Resplendent Sparks per Mythic

Crafting Availability: You can choose which Mythic Unique to craft from the Alchemist. Of course, you can also choose to purchase Mythic Unique or other D4 Items and Diablo IV Gold directly from MMOexp. 

This is a general list of Uniques and Mythic Uniques available in Diablo 4. If you're farming for any specific items or need further details about boss encounters, feel free to ask!

Recommended Reading: Diablo 4 Season 6: How to Build the Best Spiritborn

MMOexp Diablo 4 Team